Duke’s Moffitt/Caspi group just had a paper accepted for publication in Neurology entitled “Association of Pace of Aging Measured by Blood-Based DNA Methylation with Age-Related Cognitive Impairment and Dementia.”
The team found that a newly developed DNA-methylation based biomarker of the Pace of Aging, DunedinPACE, was associated with diagnosis of dementia and poorer cognitive health so that those with a faster pace of aging were more likely to have dementia and MCI and poorer scores on both ADRD screening and cognitive tests.
Citation: Sugden K, Caspi A, Elliott ML, Bourassa KJ, Chamarti K, Corcoran DL, Hariri AR, Houts RM, Kothari M, Kritchevsky S, Kuchel GA, Mill JS, Williams BS, Belsky DW, Moffitt TE, on behalf of Alzheimers Disease Neuroimaging Initiative. Association of Pace of Aging measured by blood-based DNA methylation with age-related cognitive impairment and dementia. Neurology, In press.
Outreach, Recruitment and Engagement Core publishes Summer newsletter
The first community-facing newsletter of the Duke-UNC ADRC is now up on the website. Thank you to Roseanne Tiller and Latorius Adams who did the heavy lifting. View newsletter >
Duke CTSI Announces MURDOCK Biorepository Initiative for Investigators
The Duke Clinical and Translational Science Institute (CTSI) has announced a new opportunity for Duke investigators to obtain biospecimens from the MURDOCK Study for research. The MURDOCK study is a landmark longitudinal cohort of more than 12,000 diverse participants linked to clinical data and up to 14 years of outcomes data.
The MURDOCK Biorepository Transformation Initiative, led by the Duke Kannapolis Research group, will work with Duke investigators to convert samples into rich molecular datasets by facilitating access to these samples. To make the MURDOCK samples easier to access, researchers will only incur costs for biospecimen retrieval and shipment. Learn more >
The Alzheimer’s Drug Discovery Foundation (ADDF) and Harrington Discovery Institute provide funding and drug development support of research efforts that aim to treat or prevent Alzheimer’s disease, related dementias and cognitive-decline associated with aging. Each year up to two ADDF-Harrington Scholars are chosen. The award includes:
- Two-year grant
- Funding up to $600,000
- Drug development expertise and project management support
- A personalized team of drug developers and project manager for each award recipient
- Expert business, commercialization and clinical development advice
- Regulatory assistance
- Intellectual property (IP) review and advice
- Assistance identifying and securing additional financial support based on project needs
Letter of Intent Submission Deadline: July 18, 2022
June 24, 5 pm – 7 pm & June 25, 9 am – 4:15 pm
Symposium for Learning about Alzheimer’s disease-related Medical research at Duke and UNC (SLAM-DUNC)
Duke Karsh Alumni and Visitors Center
Open to researchers, clinicians, and trainees from Duke, UNC, NCCU, UNC-Pembroke, and ECU
July 28, 4pm – 5pm
ADRD IDEAS Forum
“The Role of Selected Natural Products in Triggering the Autophagy-Lysosomal Pathway to Promote Brain Health”
Michael Fernandes de Almeida, M.S.
Biotechnology Research and Training Center
University of North Carolina – Pembroke
Join Zoom Meeting
September 21, 5:30-6 pm reception; 6 – 7 pm lecture
Karen L. Wrenn Lectureship: “On the Occasion of World Alzheimer’s Day”
Bryan Research Building, Room 103, 311 Research Drive, Durham, NC, Parking TBA
Host: Murali Doraiswamy, MBBS