ALLFTD is a multisite observational research study aimed at understanding how frontotemporal lobar degeneration (FTD or FTLD) syndromes affect the brain. This research study has a longitudinal option, consisting of one study visit a year (including fasting blood draw, cognitive testing, clinical assessment, questionnaires, MRI brain imaging and optional lumbar puncture and genetic testing) for up to five years, and a biofluid option, which is a shorter one-time visit. Frontotemporal degeneration syndromes may include behavioral variant FTD (bvFTD), Progressive Supranuclear Palsy (PSP), semantic variant or nonfluent variant primary progressive aphasia (svPPA or nfvPPA), or FTD with Amyotrophic Lateral Sclerosis (FTD/ALS). To be eligible for the study, you must:

1. Have a referring diagnosis of an FTLD clinical syndrome, be a member of a family with a strong medical history of an FTLD syndrome, or have a known genetic mutation associated with FTD.
2. Have a reliable study partner who you talk with at least once a week

Contact the study team at UNC if you are interested in learning more.