Home » Duke/UNC ADRC 2021 Symposium

Duke/UNC ADRC 2021 Symposium


9:00am – 9:30am Welcome and Overview
9:30am – 10:15am The Antimicrobial protection hypothesis of AD

Rudolph Tanzi, PhD – Harvard University

10:15am – 11:00am Alzheimer’s disease genetics implicate efferocytosis in microglia

Alison Goate, DPhil – Icahn School of Medicine of Mt. Sinai

11:00am – 11:10am Morning Break
11:10am – 12:10pm Lightning Talks Session 1:  Role of the CNS resident immune response in AD
Beth Stevens, PhD

Broad Institute and Boston Children’s

Mapping Microglia States and (Dys)Function in Alzheimer’s Disease

Carol Colton, PhD

Duke University

Role of neuroinflammation and innate immune activation in influencing brain metabolism in AD

Joseph El Khoury, MD

Harvard University

Novel animal model in the study of microglia and HSV-6

Followed by Large Group Discussion
12:10pm – 12:40pm Small Group Brainstorm 1
12:40pm – 1:20pm Lunch Break
1:20pm – 2:20pm Lightning Talks Session 2: Circulating immune responses in the Development of AD
Jenny Ting, PhD

University of North Carolina at Chapel Hill

The Role of the Inflammasome in Alzheimer’s Disease

Robyn Klein, MD, PhD

Washington University

How antiviral immune responses in the CNS might trigger pathological forgetting

David Gate, PhD

Stanford University

Intrathecal immunity in Alzheimer’s disease

Prof. Dr. Michael T. Heneka

University of Bonn

NLRP3 inflammasome activation drives pathological spread in AD

Followed by Large Group Discussion
2:20pm – 2:50pm Small Group Brainstorm 2
2:50pm – 3:00pm Afternoon Break
3:00pm – 4:00pm Lightning Talks Session 3: Pathogens and microbiome in the development of AD
Sangram S. Sisodia, PhD

University of Chicago

Sex-specific alterations in neuroinflammation and amyloid deposition by the microbiome in animal models

Rima Kaddurah-Daouk, PhD

Duke University

Brain Metabolic Health – At the Cross Road of Exposome Gut Microbiome Genome and Metabolome

Gut-Brain Chemical Axis in Alzheimer’s Disease

Serena Spudich, MD, MA

Yale University

What role(s) might COVID-19 infection play in AD development and what are the key questions and gaps

Mari L. Shinohara, PhD

Duke University

Fungal infections and fungal receptors in AD: Lessons from research on MS

Followed by Large Group Discussion
4:00pm – 4:30pm Small Group Brainstorm 3
4:30pm – 5:20pm Putting it all Together
5:20pm – 5:30pm Reconvene and Adjourn



Is this symposium free?

This symposium is 100% free thanks to the generous support from Dr. Leslie Norins (Duke Med ’62) and Ms. Rainey Norins.

What will the small discussion groups be about?

Small discussion groups will be organized by topic to identify key gaps and testable hypotheses. Small discussion groups will be encouraged to outline fundable project ideas and next steps.

Possible topic groupings include (will be modified based on areas of interest captured at registration)

The role of microglia or astrocytes in AD development and progression
Potential role of microglia in infectious etiologies underlying AD 
Potential role of astrocytes in infectious etiologies underlying AD
Blood-brain barrier and neurovascular/neurolymphatic structures in the AD pathogen hypothesis 
Role of systemic immune system in AD 
Exposure to specific pathogens and the risk of AD 
Microbiome and AD 
COVID-19 and AD 
Age-related changes in immune system or metabolism and the risk of AD 
Epidemiological approaches to probing the pathogen hypothesis of AD 
Systems biology (-omics) approaches in investigating the role of infection/inflammation in AD 
Use of animal models in studying the role of infection and inflammation in AD 
Use of brain banks and biorepositories to investigate the role of infection and inflammation in AD 
Use of novel brain imaging techniques to probe the pathogen hypothesis of AD