Goals and Activities:

• 

  Acquire conventional and novel biomarkers in biofluid (CSF, blood), brain images (PET, MRI), and other modalities (e.g., retinal imaging) in adjudicated participant groups.

• Analyze biomarkers to obtain standardized measures and support relevant funded Alzheimer’s disease (AD) research projects affiliated with the ADRC.

• Provide resources integrating multi-dimensional biomarkers data across all human subjects to assist and train ADRC researchers to investigate the underlying age-related drivers for AD.

• Disseminate our expertise and knowledge to support the AD community at large.

• Assays currently being run on ADRC samples (or available at DMPI to run on ADRC samples): CSF abeta40 and 42, tau & p-tau-181p (and plasma abeta 40 and 42 & p-tau-181p) on the Fujirebio Lumipulse platform; Quanterix HD-X platform multiplex assays for 1) NfL and GFAP; 2) Tau, NfL, UCH-L1, GFAP; and 3) Abeta40, Abeta42, GFAP, NfL

Available Resources:

1. Duke Brain Imaging and Analysis Center
2. UNC Biomedical Research Imaging Center
3. Duke Molecular Physiology Institute

Core Leaders

		Weili Lin, PhD Dixie Lee Boney Soo Distinguished Professor of Neurological Medicine, UNC Director of the Biomedical Research Imaging Center Vice Chair of Research Departments of Radiology, Neurology, Biomedical Engineering and School of Pharmacy
		Allen Song, PhD Professor in Radiology, Duke University Director of the Center for Brain Imaging and Analysis Professor in Psychiatry and Behavioral Sciences Professor in Neurobiology

Junior Associate Core Leader

Miles Berger, MD, PhD Associate Professor or Anesthesiology, Duke University Associate of the Duke Initiative for Science & Society Faculty Network Member of the Duke Institute for Brain Science

Faculty:

• Simon Davis, PhD

• Sharon Fekrat, MD

• Zibo Li, PhD

• Mingxia Liu, PhD

• Yongmei Liu, MD, PhD

• David Madden, PhD

• David Page, PhD

• Jeffrey Petralla, MD

• Robert Huynh, PharmD, MS

• Xiaopeng Zong, PhD

Staff:

• Clinical Research Specialists (TBD)