Karen L. Wrenn Lecureship

Featuring Sudha Seshadri, MD

Robert R. Barker Distinguished University Professor, Founding Director, Glenn Biggs Institute for Alzheimer’s & Neurodegenerative Diseases

“What a Heart Study Taught the World About Our Brains!”

5:00PM Reception

6:00PM Lecture

---

In the News

Congratulations to Shih-Hsiu “Jerry” Wang, PhD, who recently secured a highly competitive Alzheimer’s Association Research Grant (AARG) grant to study the role of vascular dysfunction in LATE, LATE-AD, and FTLD-TDP

In this grant proposal, Jerry will continue work with Drs. Andrew Yang and Simon Gregory to understand the molecular changes associated with these conditions through VINE-seq and Xenium spatial profiling

Jerry serves as the Core Leader of the Duke-UNC ADRC’s Neuropathology Core.

Well Deserved!

---

Workshops & Learning Opportunity

NIA Hybrid Workshop: APOE Genetics as a Major Determinant of AD Pathobiology

September 5-6, 2024

Duke/UNC ADRC ORE Core

This workshop will bring together lead investigators in APOE genetics and related fields to discuss APOE4 as a toxic gain-of-function molecule associated with the pathobiology of Alzheimer’s Disease and Alzheimer’s Disease Related Dementias (AD/ADRD). Experts in the field will address:

• Genetics related to APOE4 – consideration of different genetic populations and protective variants
• APOE-mediated mechanisms of disease
• New technologies and moving towards APOE4-targeting therapeutics
• Brainstorming session where key questions will be addressed

The outcome of the workshop will be a collection of principles by which the AD/ADRD field of genetics and related research areas can best proceed to leverage existing information on APOE in the etiology of AD/ADRD.

---

More from AAIC 2024!

AAIC additional poster presentations from the iMIND team.

Richardson A, Kundu A, Henao R, Lee T, Scott BL, Grewal DS, Fekrat S. A convolutional neural network to identify Parkinson’s disease using multimodal retinal images. Alzheimer’s Association International Conference (AAIC), 2024.

Woo J, Joseph S, Robbins CB, Haystead A, Stinnett SS, Grewal DS, Fekrat S. Longitudinal variations in retinal and neuronal degeneration in cognitively normal older adults using peripapillary optical coherence tomography angiography. Alzheimer’s Association International Conference (AAIC), 2024.

Joseph S, Haystead A, Robbins CB, Threlfall A, MacGillivray TJ, Stinnett S, Grewal DS, Fekrat S. Ultra-widefield retinal and choroidal vascular architecture in mild cognitive impairment and normal cognition. Alzheimer’s Association International Conference (AAIC), 2024.

Patel H, Robbins CB, Wisely CE, Ma JP, Singh P, Challa P, Kim T, Grewal DS, Fekrat S. Correlation of aqueous and plasma levels of phosphorylated tau181 with age and Montreal Cognitive Assessment Scores in individuals undergoing cataract surgery. Alzheimer’s Association International Conference (AAIC), 2024.

Zhao W, Robbins CB, Allen A, Joseph S, Kundu A, Hemesath A, Petrella J, Grewal DS, Fekrat S. Exploring correlations between the retinal microvascular and volumetric MRI parameters in Alzheimer’s disease and mild cognitive impairment. Alzheimer’s Association International Conference (A.AIC), 2024