Luke Bartelt

Graduate Student

Duke University
Animal Models
Cell Biology – Neurodegeneration
Neurodegeneration
Interested in understanding molecular mechanisms of Neurodegeneration through genetic mouse models and single-cell genomic technologies. Working to identify cell-type specific gene regulatory pathways driving neurodegeneration for next-generation gene therapy approaches.

Leon Coleman, M.D, Ph.D.

UNC-Chapel Hill
Animal Models
Behavioral Pathology
Cellular Pathology
The Coleman lab studies how modifiable risk factors for AD promote its cellular and behavioral pathology. By using mouse models and human tissue, we attempt to identify novel diagnostic and therapeutic targets for AD. Studies focus on underlying cellular and molecular pathology that promote AD pathogenesis and progression

Anita Disney, Ph.D.

Duke University
Animal Models
We are interested in peri- and post-menopausal macaques as a model of preclinical late-onset AD. To understand the spatial neurochemistry of the aging primate brain, we look at within-subject spatial atlases of metabolite levels (spatial metabolome), protein expression (spatial proteome), and extant pathology for the cortex and cerebellum.

William Kirby Gottschalk, Ph.D.

Duke University
Animal Models
Biomarkers
The focus of my research is to learn how alterations to core metabolic pathways contribute to mitochondrial dysfunction that underlies aging and many neurodegenerative diseases, including AD. I am also engaged in developing new genetic models of Alzheimer’s disease, that incorporate human genetic risk factors by targeted replacement.