Cell Biology

Recent research has focused on the regulation of microglial reactive oxygen species and reactive nitrogen species production as well as other cytoactive macrophage products that are made during the classical and alternative activation states associated with chronic neurodegeneration.

REC Scholar Project: Targeting autophagy to monitor age-related cognitive decline and the dementia risk

Stroke, Intracranial Aneurysms, AVMs, Cerebrovascular Disease

Dr. Axtman’s research focuses on the synthesis of small molecules that selectively modulate proteins implicated in disease-propagating pathways. She works at the interface of chemistry and biology. She is funded to develop reagents to validate novel therapeutic hypotheses related to AD.

Recent research has focused on the regulation of microglial reactive oxygen species and reactive nitrogen species production as well as other cytoactive macrophage products that are made during the classical and alternative activation states associated with chronic neurodegeneration.

The focus of the Evans lab is to mechanistically define these diverse mitochondrial quality control pathways, including mitochondrial fusion and fission events, mitochondrial derived vesicles, and mitophagy. Our goal is to understand how these pathways collaborate to regulate the mitochondrial network in healthy neurons and what goes wrong in neurodegenerative disease. We integrate advanced live-cell microscopy to visualize mitochondrial dynamics with biochemical techniques and proteomics to define the specificity of these mechanisms in primary neurons, iPSCs, and mouse models of disease.

Stroke, Intracranial Aneurysms, AVMs, Cerebrovascular Disease

Dr. Axtman’s research focuses on the synthesis of small molecules that selectively modulate proteins implicated in disease-propagating pathways. She works at the interface of chemistry and biology. She is funded to develop reagents to validate novel therapeutic hypotheses related to AD.

Bahr’s team focuses on synaptic vulnerability that contributes to AD risk factors, to improve understanding of the synaptopathy initiated by seizure- and stroke-type excitotoxicity, TBI, and blast exposures – all suspected of elevating the risk of dementia later in life.

Interested in understanding molecular mechanisms of Neurodegeneration through genetic mouse models and single-cell genomic technologies. Working to identify cell-type specific gene regulatory pathways driving neurodegeneration for next-generation gene therapy approaches.

Recent research has focused on the regulation of microglial reactive oxygen species and reactive nitrogen species production as well as other cytoactive macrophage products that are made during the classical and alternative activation states associated with chronic neurodegeneration.

The focus of the Evans lab is to mechanistically define these diverse mitochondrial quality control pathways, including mitochondrial fusion and fission events, mitochondrial derived vesicles, and mitophagy. Our goal is to understand how these pathways collaborate to regulate the mitochondrial network in healthy neurons and what goes wrong in neurodegenerative disease. We integrate advanced live-cell microscopy to visualize mitochondrial dynamics with biochemical techniques and proteomics to define the specificity of these mechanisms in primary neurons, iPSCs, and mouse models of disease.

Stroke, Intracranial Aneurysms, AVMs, Cerebrovascular Disease